CO distribution & Coronary circulation - lecture 6

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• The unit mL/min/100g shows how much of the CO that is picked up per minute in relation to 100 grams of the tissues: TRUE/FALSE true
• which organ take up most of the cardiac output if we look at %? liver
• which organ take up most of the cardiac output if we take mass into account, also wirte the unit for this? kidneys, 100ml/min/100g
• durin REST: cardiac output uptake for LIVER in %? 27%
• durin REST: cardiac output uptake for BRAIN in %? 14%
• durin REST: cardiac output uptake for HEART in %? 4%
• durin REST: cardiac output uptake for KIDNEYS in %? 20%
• durin REST: cardiac output uptake for SKELETAL MUSCLES in %? 21%
• durin REST: cardiac output uptake for SKIN in %? 5%
• durin REST: cardiac output uptake for BONES AND OTHER TISSUES in %? 9%
• during EXERCISE: cardiac output uptake for SKELETAL MUSCLES in %? 85%
• (FILL) coronary circulation: the coronary circulation gets blood from the ... ... which are conected to the ... meaning blood flow in coronary circulation is dependent on what happens in ... coronary sinuses, aorta, aorta
• (FILL) coronary circulation: the coronary sinuses branches into ... ... ... and ... ... ... left coronary artery, right coronary artery
• (FILL) coronary circulation: the 3 specific parameters of the coronary circulation is ... arterio-venous difference, ... capillary density & ... number of anatomoses high, great, high
• how many % of CO does coronary circulation recieve and how much is that in ml/min? (provid units) 4%, 200 ml/min
• how many much of the CO does coronary circulation recieve if we take its MASS into account ..-.. ? (provid units) 70-100 ml/min/100g
• High arterio-venous difference means it has much more ... blood compered to ... blood -> meaning it gives away a lot of .. venous, arterial, O2
• how much O2 per 100 ml of blood is it in the BEGENING of coronary arteries? (COPY THIS: .. ml per 100 ml of blood) 20 ml per 100 ml of blood
• how much O2 per 100 ml of blood is it in the END of coronary arteries? (COPY THIS: .. ml per 100 ml of blood) 5 ml per 100 ml of blood
• how many % of the oxygen is secreted out of the coronary circulation? 75%
• how many capillaries per mm2 is it in the coronary circulation? (COPY THIS: .. capillaries per mm2) 3000 capillaries per mm2
• Great capillary density is necessary to increase CO2 delivery to the heart: TRUE/FALSE false
• (FILL) If a branch of the blood vessel is blocked, blood can take an alternative route through ... anastomoses
• During systole --> coronary arteries are compressed --> blood flow here ecreases: TRUE/FALSE true
• During diastole --> coronary arteries are relived from compression --> blood flow here increases: TREU/FALSE true
• (FILL) in LEFT coronary artery during isovolumetric contraction of ventricle the blood flow in coronary artery approches .. ml/min because the artery will become ... by the contraction 0, compressed
• (FILL) in LEFT coronary artery during ejection of ventricle the blood flow in coronary artery ... a little compered to during isovolumetric contraction increases
• (FILL) in LEFT coronary artery during isovolumetric relaxation of ventricle the blood flow in coronary artery ... a lot (up to .. ml/min) -> this happens because pressure in ... is high and also bc ventricles will not compress the coronary arteries increase, 400, aorta
• (FILL) in LEFT coronary artery during the end of diastole the blood flow in coronary artery will ... beacuse pressure in aorta ... meaning ... pressure difference decrease, decrease, decreased
• Pressure in aorta is always BIGGER than pressure in right ventricle during whole cardiac cycle thus right coronary artery branches are not completely compressed bc it will have pritty high blood pressure all the time: TRUE/FALSE true
• (FILL) in RIGHT coronary artery during the end of diastole the blood flow in coronary artery will ... beacuse pressure in aorta ... meaning ... pressure difference decrease, decrease, decreased
• (FILL) in RIGHT coronary artery during the ejection of ventricle the blood flow in right coronary artery will ... because pressure in aorta ... meaning ... pressure difference increase, increase, increased
• (FILL) in RIGHT coronary artery during isovolumetric relaxation of ventricle the blood flow in right coronary artery will ... a little -> because the ventricle will not ... as much on the coronary artery increase, compress
• which of the coronary arteries recieves most of the blood, left of right? left
• what are the 3 most important factors that influence coronary blood flow? diastolic pressure in aorta, heart rate, diameter of coronary arteries
• When cardiac cycle shortens -> diastole shortens more than systole -> Shortened diastole -> coronary blood flow decreases because the left ventricle receives the most blood during diastole -> less blood pumped out to aorta -> less pressure differnce: TRUE/FALSE true
• peripheral METABOLIC regulation: for vasoDILATION to occur -> ... of PCO2, ... pH, ... PO2, ... Adenosine, ... K+ increase, decrease, decrease, increase, increase
• peripheral METABOLIC regulation: for vasoCONSTRICTION to occur -> ... of PCO2, ... pH, ... PO2, ... Adenosine, ... K+ decrease, increase, increase, decrease, decrease
• Myogenic regulation can provide relatively constant blood flow to the coronary circulation if Mean arterial pressure changes between 70-150 mmHg: TRUE/FALSE true
• In case of blood vessel damage, platelets and injured tissues release the vasoconstricters serotonin and thromboxane A2 -> vasoconstriction to prevent blood loss: TRUE/FALSE true
• Sympathetic vasodilator fibres & Parasympathetic vasodilator fibres Both release Acetylcholine on M3 receptors on the endothelial cell -> NO release -> cGMP in SM cell -> relaxation: TRUE/FALSE true
• Sympathetic vasoconstrictor fibres Release NE on α1 receptors on the smooth muscle cells -> vasoconstriction: TRUE/FALSE true

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