Epigenetic variability and functions

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• (FILL) epigenetic variability refers to changes in gene expression that occur ... alterations to the DNA sequence -> These changes are done by modifications to DNA and its associated proteins such as ..., which can influence how genes are expressed without, histones
• (FILL) epigenetics will change the amount of ... ... without changeing the .. ... genes expressed, DNA sequence
• Epigenetic changes can have significant impacts on an organism's traits and health outcomes, as they can regulate gene activity without altering the genetic code itself: TRUE/FALSE true
• write the 5 things that can happen due to epigenetic changes (when something is wrong with the epigenetic veriablility system): (5st) cancer, neurological disorders, cardiovascular diseases, metabolic disorders, autoimmune diseases
• epigenetic changes in CANCER cells can lead to ... of tumour ... genes or the activation of ... silencing, suppressor, oncogenes
• which are the 3 types of epigenetic changes that happens in cancer development and causes cancer? (3st) DNA methylation, histone modification, alterations in non-coding RNAs
• problems in epigenetic variability has been linked to various neurological disorders including Alzheimer’s disease, Parkinson´s disease and schizophrenia: TRUE/FALSE true
• Cardiovascular disease --> epigenetic changes here can affect the expression of genes involved in vascular ..., ... ... cell proliferation and ... function. E.g., this can then cause ..., ... and ... ... inflammation, smooth muscle, endothelial, atherosclerosis, hypertension, heart failure
• Epigenetic-based treatments can e.g. be DNA methylation inhibitors and histone deacetylase inhibitors: TRUE/FALSE true

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