Bioinformatik - Comparative modelling

The exercise was created 31.05.2022 by PopcornDidde. Anzahl Fragen: 6.

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  • Step 0 Get to know your protein.
  • Step 1 Sequence search. Find proteins with known 3D structures that are homologous (>40% identity) to your target sequence
  • Step 2 MSA & template selection. Make an MSA with target and multiple homologous sequences (with known 3D). Select the longest matching sequence as template. Run PSA on template and target.
  • Step 3 Build a 3D model. Use template and PSA to build new 3D model. Replace non-identical aa with those from target.
  • Step 4 Optimization. Optimize model, in silico testing.
  • Step 5 Validation. Checking if factors make sense. Ramacandran, bond lengths, bond angles, steric clashes. If necessary, repeat steps 2 and 3.

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Freigegebene Übung

https://spellic.com/ger/abfrage/bioinformatik-comparative-modelling.10974615.html

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