CD - antigens

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• CD3 is expressed by T-cells, B-cells, Monocytes
• "Associated with the T-cell antigen receptor (TCR). Required for cell-surface expression of and signal transduction by the TCR" CD3
• "Adhesion molecule, binding CD58 (LFA-3). Binds Lck intracellularly and activates T cells" CD2
• "Co-receptor for MHC class II molecules. Binds Lck on cytoplasmic face of membrane." CD4
• "Attenuates TCR signaling. Enhances Akt signaling in T cells. Required for optimal TH2 and TH17 differentiation" CD5
• "Co-receptor for MHC class I molecules. Binds Lck on cytoplasmic face of membrane" CD8
• "co-receptor for B cells" CD19
• "may form a Ca2+ channel; possible role in regulating B-cell activation; involved in B-cell development and plasma B-cell differentiation" CD20
• "target for Rituximab" CD20
• "IL-2 receptor alfa chain" CD25
• "activation of naive T cells, receptor for co-stimulatory signal, binds B7. and B7.2" CD28
• "Binds CD40L; receptor for co-stimulatory signal for B cells, promotes growth, differentiation, and isotype switching of B cells, and promotes germinal center formation and memory B-cell development; promotes cytokine production by macrophages and dendritic cells" CD40
• "Binds complement components C8 and C9, blocks assembly of membrane-attack complex" CD59
• "Co-stimulator, ligand for CD28 and CTLA-4" CD80, B7
• "MHC class I-like molecule, associated with ȕ2-microglobulin. Has specialized role in presentation of lipid antigens" CD1

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