Medical chemistry. What does this drug do?

Chloropromazine D₂ receptor antagonist (competitive), D_2 and 5HT_2 receptors reversible COX inhibitors, D_2, 5HT_2A, D_4 receptors antagonists

Phenothiazine D₂ receptor antagonists (competitive), serotonin reuptake inhibitor (competitive and reversible), Irreversible enzyme inhibitors of MAO-A/B

Thioxanthenes D₂ receptor antagonists (competitive), reversible COX inhibitors, Dual competitive antagonists at α₁ + β receptors

Phenylbutanones D_2 and 5HT_2 receptors reversible COX inhibitors, D_2, 5HT_2A receptors reversible COX inhibitors

Dibenzodiazepines D_2 and 5HT_2A and D_4 receptors antagonists, 5-HT₂A antagonist weak D₂ antagonist plus others (Competitive antagonism)

Clozapine 5-HT₂A antagonist weak D₂ antagonist plus others (Competitive antagonism), Reuptake inhibitors of NE/5-HT (competitive reversible)

TCAs Reuptake inhibitors of NE/5-HT (competitive and reversible) Also antagonists at muscarinic H₁ and α₁ receptors, D₂ receptor antagonists (competitive)

Clomipramine Inhibits reuptake for norepinephrine and seratonin (competitive and reversible), NET inhibition (more selective than TCAs) Reversible competitive inhibitors of NE transporters

Selective norepinephrine reuptake inhibitors (sNRI) NET competitive inhibitor, D_2 competitive antagonist

Selective Serotonin Reuptake Inhibitors (sSRIs) SERT reversible competitive inhibitor, Irriversible inhibitors of MAO A/B

Phenoxyphenylalkylamine SERT competitive reuptake inhibitor, Suicide substrate of MAO A/B

MAOI Antidepresants Irreversible enzyme inhibitors of MAO-A/B, Reversible enzyme inhibitors of MAO-A/B, Suicide substrate competitive enzyme inhibitors of MAO-A/B

Benzodiazepines Positive allosteric modulators (PAMs) of GABA_A receptors (Not agonists not inhibitors), Reversible competitive inhibitors of the serotonin transporter (SERT)

Acetazolamide Carbonic anhydrase inhibitors Reversible competitive, Inhibitors (competitive) of NKCC2 cotransporter, Carbonic anhydrase inhibitors Irreversible competitive

Brinzolamide Carbonic anhydrase inhibitors Reversible competitive, Carbonic anhydrase inhibitors irriversible competitive, Carbonic anhydrase antagonist Reversible competitive

Furosemide, Bumetanide Inhibitors (competitive) of NKCC2 cotransporter, Carbonic anhydrase inhibitors reversible competitive

Thiazides Inhibit NCC (NaCl cotransporter) in distal tubule (competitive like), Inhibitors (competitive) of NKCC2 cotransporter

Amiloride, Spironolacton ENaC (epithelial Na⁺ channel) antagonist, β₁/β₂ receptor antagonists (competitive)

ß1- and ß2- receptor blockers β₁/β₂ receptor antagonists (competitive), β₁/β₂ receptor agonist (competitive), β₁/β₂ receptor inhibitors (competitive).

Selective ß1- receptor blockers Competitive antagonists at β₁, Competitive irreversible inhibitors at β₁, Competitive agonist at β₁

Alpha- and beta- receptor blockers Dual competitive antagonists at α₁ + β receptors, Dual competitive agonists at α₁ + β receptors, Dual competitive inhibitors at α₁ + β receptors

Lisinopril Competitive ACE inhibitor, Dual competitive antagonists at α₁ + β receptors, Angiotensin II AT₁ receptor antagonists (competitive)

Nitrovasodilators Does not effect enzymes or receptors, L-type calcium channel blockers (antagonists), PPAR-α agonists (nuclear receptor agonists)

Calcium entry antagonist L-type calcium channel blockers (antagonists), Does not effect enzymes or receptors, Competitive inhibitors of HMG-CoA reductase

Fibrats PPAR-α agonists (nuclear receptor agonists), Competitive inhibitors of HMG-CoA reductase, Competitive irreversible inhibitors of HMG-CoA reductase

Statins Competitive inhibitors of HMG-CoA reductase, Competitive agonists of HMG-CoA reductase, PPAR-α agonists (nuclear receptor agonists)

HMG-CoA reductase inhibitors Competitive, non-competitive, The name is wrong since they are receptors

Heparin-Based Drugs Activator of antithrombin III (non-competitive), Direct competitive inhibitor of thrombin/Xa, Neither enzyme nor receptor effecting drug

Factor Xa-inhibitores Direct active-site reversible inhibitors of Xa, Indirect active-site reversible inhibitors of Xa, irreversible inhibitors of Xa

Argatroban Direct thrombin inhibitor (reversible), Direct active-site reversible inhibitors of Xa, rreversible enzyme inhibitor of COX-1 (suicide inhibitor via acetylation)

Acetylsalicyl acid Irreversible enzyme inhibitor of COX-1 (suicide inhibitor via acetylation), Reversible enzyme inhibitor of COX-1 (suicide inhibitor via acetylation), Direct thrombin inhibitor (reversible)

Dipyridiamol PDE inhibitor and adenosine uptake inhibitor (reversible), PDE inhibitor and noradrenaline uptake inhibitor (reversible), PCE inhibitor (competitive, reversible)

Clopidogrel Irreversible (suicide) inhibitor of the P2Y₁₂ receptor after activation, PDE inhibitor and adenosine uptake inhibitor (reversible), Irreversible enzyme inhibitor of COX-1 (suicide inhibitor via acetylation)

Ticagrelor, Cangrelor Reversible antagonists of P2Y₁₂, GP IIb/IIIa antagonists (competitive inhibitors of fibrinogen binding)

Eptifibatid, Tirofiban GP IIb/IIIa antagonists (competitive inhibitors of fibrinogen binding), Reversible antagonists of P2Y₁₂, Irreversible (suicide) inhibitor of the P2Y₁₂ receptor after activation

Antifibrinolytic Agents Competitive inhibitors of plasminogen activation, Non-competitive inhibitors of plasminogen activation, Irreversible inhibitors of plasminogen activation.

zanamivir transition-state inhibitor of neuraminidase, Suicide inhibitors of PBPs

Penicillins Suicide inhibitors of PBPs, Transition-state inhibitor

Cephalosporins Transpeptidase Irriversible Inhibitor, Suicide inhibitors of PBPs, Reversible antagonists of P2Y₁₂ (non-competitive allosteric for Cephalosporins)

Thienamycin Transpeptidase Irriversible bond Resistant towards ß-Lactamase enzyme, TSI of PBPs, PDE inhibitor and adenosine uptake inhibitor (reversible)

Monobactams Transpeptidase Irriversible bond, DHPS reversible inhibition

Clavulanic acid Enzyme: ß-Lactamase Effect: Suicide substrate, Transpeptidase Effect: Irriversible bond

Sulbactam and Tazobactam Enzyme: ß-lactamases Effect: Suicide substrate, Enzyme: dihydropteroate synthase (DHPS) Effect: Prodrug Reversible inhibition

Sulphonamides: Enzyme: dihydropteroate synthase (DHPS) Effect: Prodrug Reversible inhibition, Enzyme: ß-lactamases Effect: Suicide substrate, Enzyme: ß-lactamases Effect: TSI

Vancomycin and analoges Enzyme: Any enzyme doing transglycosidation Not inhibitors in classical sense: bind substrate (D-Ala-D-Ala) → block cell wall synthesis, Enzyme: dihydropteroate synthase (DHPS) Effect: Prodrug Reversible inhibition

Neu5Ac2en Mimmics: Sialic acid Enzyme: Neuraminidase Effect: TSI, Not inhibitors in classical sense: bind substrate (D-Ala-D-Ala) → block cell wall synthesis

4-Amino-Neu5Ac2en (zanamivir): Mimmics: Sialic acid. Neuraminidase. Effect: TSI, Effect: Prodrug Reversible inhibition. Enzyme: dihydropteroate synthase (DHPS).

Saquinavir, Ritonavir, Lopinavir Mimmics: Intermediate of Phe-Pro chain. Enzyme: HIV-Protease. HIV protease inhibitors, Mimmics: Sialic acid. Neuraminidase. Effect: TSI

Geftitinib Enzyme: Protein Kinases. Reversible competitive inhibitor of EGFR tyrosine kinase, Enzyme: Tyrosine Kinase. inhibits KIT and PDGFR. Competitive inhibitor of BCR-ABL kinase (ATP-binding site).

Second generation kinases inhibitors Enzyme: Bosutinib (protein Abl and Src) or GNF-2 (Bcr-Abl). Competitive inhibitors, Selective inhibitor for hybrid tyrosine kinase (Bcr-Abl). Enzyme: Tyrosine Kinase

Sorafenib Proteine kinase (tyrosine). Multi-kinase inhibitor (competitive ATP-site inhibitor), Type I inhibitor. EGFR inhibitor

Acetazolamide, Brinozolamide Enzyme: Carbonic anhydrase inhibitor. Reversible CA inhibitors, NKCC2 cotransporter. NKCC2 inhibitors.

Furosemide, Bumetanide NKCC2 cotransporter. Inhibitor, Enzyme: Carbonic anhydrase inhibitor (reversible).

Thiazides NCC inhibitors, ENaC blocker & Aldosterone antagonist

Amiloride, Spironolacton ENaC blocker & Aldosterone antagonist, NCC inhibitors, NKCC2 cotransporter. NKCC2 inhibitors.

Chloropromazine Anti-psychotic, Anti-depressents, Cures hypertention

Phenothiazine Anti-psychotic, Anti-depressents, Cures hypertention

Thioxanthenes Anti-psychotic, Anti-depressents, Cures hypertention

Phenylbutanones Anti-psychotic, Anti-depressents, Cures hypertention

Dibenzodiazepines Anti-psychotic, Anti-depressents, Cures hypertention

Clozapine Anti-psychotic, Anti-depressents, Cures hypertention

Tricyclic Antidepressents (TCAs) Anti-depressents, Cures hypertention, Anti-psychotic

Clomipramine Anti-depressents, Cures hypertention, Anti-psychotic

Selective norepinephrine reuptake inhibitors (sNRI) Anti-depressents, Cures hypertention, Anti-psychotic

Selective Serotonin Reuptake Inhibitors (sSRIs) Anti-depressents, Cures hypertention, Anti-psychotic

Phenoxyphenylalkylamine Anti-depressents, Cures hypertention, Anti-psychotic

MAOI drugs Anti-depressents, Cures hypertention, Anti-psychotic

Benzodiazepines Sedative-Hypnotic and Anxiolytic Agents, Anti-depressents, Cures hypertention, Anti-psychotic

Acetazolamide Cures hypertention, Anti-psychotic, Anti-depressents

Brinzolamide Cures hypertention, Anti-psychotic, Anti-depressents

Furosemide, Bumetanide Cures hypertention, Anti-psychotic, Anti-depressents

Thiazides Cures hypertention, Anti-psychotic, Anti-depressents

Amiloride, Spironolacton Cures hypertention, Anti-psychotic, Anti-depressents

Beata-blockers Cures hypertention, Anti-psychotic, Anti-depressents

ß1- and ß2- receptor blockers Cures hypertention, Anti-psychotic, Anti-depressents

Selective ß1- receptor blockers Cures hypertention, Anti-psychotic, Anti-depressents

Alpha- and beta- receptor blockers Cures hypertention, Anti-psychotic, Anti-depressents

Lisinopril Cures hypertention, Anti-psychotic, Anti-depressents

AT1 blockers/angiotensin-receptor inhibitors Cures hypertention, Anti-psychotic, Anti-depressents

Nitrovasodilators Cures hypertention, Anti-psychotic, Anti-depressents

Calcium entry antagonist Cures hypertention, Anti-psychotic, Anti-depressents

Fibrats Cholesterol lowering drug, Anticoagulants, Anti-virus

Statins Cholesterol lowering drug, Anticoagulants, Anti-virus

HMG-CoA reductase inhibitors Cholesterol lowering drug, Anticoagulants, Anti-virus

Anticoagulants Anticoagulants, Anti-virus, Cholesterol lowering drug

Heparin-Based Drugs Anticoagulants, Anti-virus, Cholesterol lowering drug

Factor Xa-inhibitores Anticoagulants, Anti-virus, Cholesterol lowering drug

Argatroban Anticoagulants, Anti-virus, Cholesterol lowering drug

Acetylsalicyl acid Anticoagulants AND painkiller, Anti-virus, Cholesterol lowering drug

Dipyridiamol Anticoagulants, Anti-virus, Cholesterol lowering drug

Clopidogrel Anticoagulants, Anti-virus, Cholesterol lowering drug

Ticagrelor, Cangrelor Anticoagulants, Anti-virus, Cholesterol lowering drug

Eptifibatid, Tirofiban Anticoagulants, Anti-virus, Cholesterol lowering drug

Prostaglandin derivatives Anticoagulants, Anti-virus, Cholesterol lowering drug

Antifibrinolytic Agents Coagulants, Anti-virus, Cholesterol lowering drug

zanamivir Anti-virus, Cholesterol lowering drug, Anticoagulants

Penicillins Antibiotic, Anti virus, Anti cancer

Cephalosporins Antibiotic, Anti virus, Anti cancer

Thienamycin Antibiotic, Anti virus, Anti cancer

Monobactams Antibiotic, Anti virus, Anti cancer

Clavulanic acid Antibiotic (kind of), Anti virus, Anti cancer

Sulbactam and Tazobactam Antibiotic (kind of), Anti virus, Anti cancer

Sulphonamides Antibiotic, Anti virus, Anti cancer

Vancomycin and analoges Antibiotic, Anti virus, Anti cancer

Neu5Ac2en Anti virus, Anti cancer, Antibiotic

4-Amino-Neu5Ac2en (zanamivir) Anti virus, Anti cancer, Antibiotic

Saquinavir, Ritonavir, Lopinavir Anti virus, Anti cancer, Antibiotic

Geftitinib Anti cancer, Antibiotic, Anti virus

Imatinib Anti cancer, Antibiotic, Anti virus

Second generation kinases inhibitors Anti cancer, Antibiotic, Anti virus

Sorafenib Anti cancer, Antibiotic, Anti virus

Acetazolamide, Brinozolamide Cures hypertention, Anti-psychotic, Anti-depressents

Furosemide, Bumetanide Cures hypertention, Anti-psychotic, Anti-depressents

Thiazides Cures hypertention, Anti-psychotic, Anti-depressents

Amiloride, Spironolacton Cures hypertention, Anti-psychotic, Anti-depressents

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