Pharma collo 1 läkemedel

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• Fenoterol D β2 adrenoreceprtor agonist, bronchodilator & astma medication. Short acting. Has cardiovascular toxicity
• Salbutamol D β2 selective agonist, Bronchodilator, asthma medication , treat high blood pottasium levels
• Formoterol, Sameterol Agonist β2 receptor, LABA’s, bronchodialator & COPD
• Timolol Non-selective β antagonist (blocker), Glaucoma, for reducing intraocular pressure
• Noradrenalin Agonist α & β1 receptor, Vasoconstriction, for shock
• Xylometazoline, Naphozoline Agonist α1 & α2, Decongestant (i.e nasal) & rhinitis treatment —> causes vasoconstriction
• Carteolol Non-selective β antagonist, Glaucoma
• Nebivolol Antagonist β1 (dose dependent), Vasodilation (because β blocker) treats hypertension. Causes release of NO (vasodialator)
• Metoprolol Antagonist β1 blocker, Treatment for tachycardia hypertension treatment
• Carvedilol Antagonism nonselec β & α1, Causes vasodilation for α receptors — β receptor causes lowering blood pressure. Treating hypertension & heart failure. Beneficial due to dual effects receptor antagonism
• Betaxolol non-selective, B antagaonist, used to treat galucoma & hypertension
• Bisoprolol B1 antagonist, Chronic heart failure treatment, also for hypertension
• Phenylephrine Agonist α receptor, Used for conjunctival itching, rhinitis, decongestant (allergy)
• Tamsulosin Antagonist for α1a receptor (α1a in prostate, α1b in vessels),Used in men with being prostate hyperplasia, prevents urinary retention. Due to α1a it will not cause hypotension
• Mirabegron β3 Agonist, Used to treat overactive bladder —> bladder relaxation
• Esmolol B1 anatgonist, Short acting, used for terminating tachycardia, & hypertension/ arrythmia during anasthesia
• Prasozin α1 antagonist,Treat high blood pressure & PTSD. & for urinary hesitancy
• doxazosin antagonist α1, Longer acting, treats hypertension, + prostat5c hyperplasia
• Propanolol Non-selective β antagonist, Treat high blood pressure, treats tachycardia associated with hyperthyroidism. Performance anxiety treatment
• Brimonidine Agonist for α2 receptors, Lower intraocular pressure with open angle glaucoma by vasoconstriction
• Atropine Non-selective competitive muscarinic antagonist, Treat GI hypermotility, decrease GI secretions. Treats bradycardia
• Pilocarpine Nonselective muscsrininc(M3) agonist, Treats glaucoma, causes constriction of pupils(miosis), increase salivation/lacrimal secretion = treats xerostomia
• tropicamide nonselective m. antagonist, causes pupillary dialation(midrasis), shorter duration than atropine
• Ipratropium bromide Nonselective for m. Antagonist, Inhalation treatment for asthma & COPD. Not cross BBB
• Tiotropium bromide Antagonist for M3 receptors, Asthma & COPD treatment causes bronchodialation
• Solifenacin, Darifenacin Antagonist for M3 receptors, Treat urinary incontinence, relaxes bladder
• Butylbromide hyoscine Non selective muscarinic antagonist, NO CNS EFFECT. Treats GI hypermotility
• Nicotine, Wereniklina (varenicline), cytisine agonist for nicotinic, Treat nicotine addiction,
• Suxamethonium agonist nicotinic receptor in NMJ, Its a depolorizing agent; used for muscle relaxation. For short-term paralysis/anaesthesiaKidney elimination (longer duration)
• To treat alzheimers diesease Donepezil , Rivastigmin
• Treatment of nicotine addiction Nicotine • Varenicline • Cytisine
• Decongestants (α agonists) Xylometazoline • Naphozoline • Phenylephrine
• ACh esterase blockers; acting at NMJ for myasthenia gravis Neostigmine • Physostigmine • Donepezil • Rivastigmin • (Rocoronium, blocking nicotinic receptors at NMJ) • Edrophonium (diagnostic due to short duration)
• Incontinence Tamsulosin (also for benign prostate hyperplasia) • Mirabegron • (Prazosin) • Doxazosin• Solifenacin • Darifenacin
• Asthma & COPD —> bronchodilator Fenoterol • Salbutamol (albuterol) • Formoterol Pancuronium Antagonist nicotinic receptors at NMJ Non-depolarising muscle relaxant. Has vagolytic activity — > increases heart rate Used w. anaesthesia. Execution & suicide. Kidney elimination (longer duration) 35-60min Rocuronium Antagonist nicotinic receptor at NMJ Non-depolarising, used for skeletal muscle relaxation Liver elinmination (shorter duration) 10-20min Neostigmine Indirect agonist for nicotinic/ muscarinic receptors Cholineesterase inhibitor, treats myasthenia gravis. Interferes breakdown of AcH. 2-4h Physostigmine Inhibitor of cholinesterase Antidote for atropine poisoning. Crosses BBB(seizures). For glaucoma Donepezil Acethylcholinesterase inhibitor, inhibiys hydrolysis of AcH Alzheimers treatment Rivastigmin Acethylcholinesterase inhibitor Alzheimers treatment. Crosses BBB Pralidoxime Binds to unblocked sites of acetylcholinesterase enzyme & displaces the inhibiting agent Antidote for acethylcholinesterase inhibitors. Reactivates acetylcholinesterase Edrophonium Reversible ach esterase inhibitor in NMJ Diagnostic use for differentiating myasthenia gravis from other diseases. Short acting Methacoline Agonist for muscarinic receptor Diagnosis of bronchial hyperactivity (asthma COPD), used to evaluate how reactive/ sensitive lungs are to environment causes hypotension&bradycardia • Pilocarpine • Ipratropium bromide • Tiotropium bromide • Metacholine• Salmeterol • (Epinephrine)
• Β blockers treatment of hypertension etc Metoprolol asoconstrictors treating hypotension • Norepinephrine • Epinephrin
• Lowering intraocular pressure —> Glaucoma Timolol • Carteolol • Betaxolol • Brimonidine • Pilocarpine

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