Cytokines

Antiviral, increased MHC class I expression IFN-alfa

Antiviral, increased MHC class I expression IFN-beta

Macrophage activation, increased expression of MHC molecules and antigen processing components, Ig class switching, supresses TH17 and TH2 IFN-gamma

Fever, T-cell activation, macrophage activation IL-1

Treg maintenance and function, T-cell proliferation and differentiation IL-2

Synergistic action in early hematopoiesis, knock-out = : impaired eosinophil development. Bone marrow unresponsive to IL-5 IL-3

B-cell activation, IgE switch, induces differentiation into TH2 cells IL-4

Eosinophil growth, differentiation IL-5

T- and B-cell growth and differentiation, acute phase protein production, fever IL-6

Growth of pre-B cells and pre-T cells, and ILCs IL-7

Mast-cell enhancing activity, stimulates TH2 and ILC2 cells IL-9

Potent suppressant of macrophage functions IL-10

Activates NK cells, induces CD4 T-cell differentiation into TH1-like cells IL-12

B-cell growth and differentiation, inhibits macrophage inflammatory cytokine production and TH1 cells, induces allergy/asthma IL-13

Induces cytokine and antimicrobial peptide production by epithelia, endothelia, and fibroblasts, proinflammatory IL-17

Germinal center maintenance induces proliferation of B, T, and NK cells IL-21

Induces production of antimicrobial peptides; induces liver acute-phase proteins, pro-inflammatory agents; epithelial barrier IL-22

Part of responce to fungi, induces proliferation of TH17 memory T cells, increased IFN-gamma production IL-23

Promotes inflammation, endothelial activation TNF-alfa

B-cell activation, class switching CD40L

Stimulates T-cell proliferation CD27L

Stimulates T- and B-cell proliferation CD30L

Click