Pharma collo 2

The exercise was created 2019-05-24 by Deborahshako. Question count: 36.

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  • Clavulanic acid is a an... beta-lactamase inhibitor​
  • Simultaneous administration of cephalosporins and anticoagulants as Warfarin.... risk of bleeding
  • medicines is a pro-drug ​(first inactive > metabolized > active) ribavirin
  • Acyclovir can be used against... herpes virus
  • ​Oseltamivir, ​Zanamivir can be used against... influensa virus
  • Ribavirin can be used against.. hepatitis C virus
  • Zanamivir used against influenca virus.. given in inhalation and is well tolerated
  • Macrolides (Erythromycin, clarithromycin, azithromycin) against influenca virus.. is given intravenousy and causes arrhythmias
  • Azole antifungal drug, By blocking fungal enzyme responsible for lanosterol into ergosterol transformation fluconazole
  • inhibiting dna production in fast dividing dividing cells, cause fearst bleeding and diarrhea, blocking reproductive cell production, hand foot syndrome flucytozine
  • Antifungal for topical and systemic use, high cumulative in the nails and keratin rich cells, which can be used once and be active for 30 days terbinafine
  • Blocking of haem-polymerase is a mechanism of action of chloroquine (antimalaria drug)
  • Plant derivative, used with lumefantrine Artemisine
  • Psychiatric side effects can be observed especially during therapy with... mefloquine
  • Folate antagonist, used together with Atovaquone, never used alone proguanil
  • Treatment for leprosy, hemolysis of RBC in longer period of treatment dapsone
  • Second generation III receptor antagonist vs. first generation III receptor antagonist produces less side effects
  • A serotonin 5-HT3 receptor antagonist (e.g. granisetron), can be used as... antiemetic to treat nausea following chemotherapy
  • Azithromycin is a macrolide, so it is... bacteriostatic
  • Fluconazole is an ​enzymatic inhibitor ​, and ​rarely cause life threatening side effects true
  • Mechanism of action of macrolides is... inhibition of protein synthesis
  • Mechanism of action of B-lactams and Glycopeptides inhibition of cell wall creation
  • Mechanism of action of Quiniloles Inhibitoon of DNA Polymerase
  • Metabolism of isoniazid depends on activity of enzymes. There are two groups, slow and fast metabolizers, with different toxicity profiles. isoniazid is metabolized mainly by... acetylation ​(liver)
  • Co-Trimoxazole (Sulfonamides) is acting as progunalil, by: inhibition of folate synthesis
  • Side effects of fluoroquinolones prolonged QT interval and torsades de pointes ​(And macrolides, and many others), tendonitis, liver toxicity
  • During pregnancy can be safely used.. amoxicillin
  • By acting on topoisomerase-II ​ ciprofloxacin
  • Antiprotozoal medication: ​Nucleic acid synthesis; Create free radicals metronidazole
  • Ethambutol specific toxicity is.. Optic neuritis, cause red-green colorblindness
  • Patient who show allergic reactions for β-lactams, should not be treated with cephalosporins
  • Macrolides ● Streptogramines ● Clindamycin (Lincosamide) ● Linezolid ● Chloramphenicol Inhibit 50S subunit
  • Tetracyclines ● Aminoglycosides ● Tigecycline Inhibit 30S subunit:
  • abacavir ● maraviroc ● Didanosine ● Emtricitabine ● Lamivudine ● Stavudine ● Tenofovir For HIV
  • Combined with metal-ions (vitamins, dairy products, micro-/macroelement pills) will have a diminished bioavailability: Fluoroquinolones ● Tetracyclines
  • Antibiotics combined oral contraceptives (ex. P-pills), reduces the contraceptive pills: Rifampicin, Rifabutin

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